Rapid test for Clostridioides difficile
GDH and Toxin A/B combination in a double cartridge!
Clostridioides difficile (formerly: Clostridium difficile) associated diseases (CDAD) are the most frequently identified causes of nosocomial diarrhoea and the most important diarrhoeal disease of inpatients in Germany. The BIOMED combined test enables the identification of GDH (glutamate dehydrogenase), toxin A and B in one step.
According to § 6 paragraph 1 No. 5a IfSG C. difficile must be reported to the public health department for severe cases of illness and for all infections caused by the ribotypes 027 and 078.
Advantages of the combined rapid test:
Easy and safe test handling
Testing of several factors simultaneously
Rapid assessment using the one-step immunochromatic rapid test
Rapid containment of disease outbreaks by reducing the risk of infection
Reliable exclusion of CDAD
Ready-to-use test kit with all necessary materials
Test result visible after 15 minutes
Targeted therapy for improved patient care
Performance data
| Pathogens | Sensitivity | Specificity | Repeatability |
|---|---|---|---|
| GDH | 95,0 % | 99,0 % | 100 % |
| Toxine A and B | 94,6 % | > 99,9 % | 100 % |
Clostridioides difficile
Clostridioides difficile associated diseases (CDAD) are the most frequently identified causes of nosocomial diarrhoea and the most important diarrhoeal disease of inpatients (about 20 to 40 % of hospital patients are colonized with C. difficile) in Germany.
Clostridioides difficile is a spore- and toxin-forming Gram-positive rod bacterium, which is one of the bacteria found in the intestinal flora of 3% of healthy adults. It is much more common in infants, but rarely causes problems.
The outbreak of a disease or proliferation of the bacterium is usually the result of a disturbance of the intestinal flora, whether through antibiotic treatment, colonoscopy or other interventions, by which competing types of normal intestinal colonisation are suppressed. As a consequence of this altered intestinal flora, C. difficile can proliferate and produce and release toxins (toxins A and B) that damage the intestinal wall, causing infectious diarrhoea (Clostridioides difficile infection, abbreviation CDI) and possibly leading to life-threatening pseudomembranous colitis.
The bacterium with high environmental resistance (spores insensitive to heat and many disinfectants) is transmissible from person to person. Over 80% of the reported diseases occur in the older generation (> 65 years).
