Immunoassay quality controls
BIOMED quality controls for immunoassays and monitoring of drug level settings are available in three different levels. They contain comprehensive target values and reference ranges for thyroid diagnostics, TDM (therapeutic drug monitoring) and toxicology, tumour markers for the diagnosis of different tumour entities, endocrine markers for the determination of hormone status, markers for reproductive medicine and other areas.
Parameters of thyroid diagnostics
Hyper- or hypo-function of the thyroid gland is indicated by changes in thyroid hormones. Therefore the determination of hormones in serum can be used for diagnosis, but also for monitoring the course of thyroid diseases.
The thyroid-stimulating hormone TSH (also: thyrotropin) is formed d in the pituitary gland. The hormone reaches the thyroid gland via the bloodstream, where it stimulates the production of thyroid hormones.
The storage form of the thyroid hormone, the iodine glycoprotein thyroglobulin (TG, also thyroglobulin), is mainly used for the follow-up control of thyroid tumours.
Endocrinology is the study of the morphology and function of glands with internal secretion (endocrine glands) of hormones and their disorders.
In the field of reproductive medicine, the basic principles of reproduction, the control of human fertility and disorders of fertility (sterility) are studied. Another area is the formation or disorders in the development of sexual characteristics.
Tumour markers by type of tumour
Tumour markers are proteins, peptides or other biological substances in the blood whose increased concentration can indicate a tumour or the recurrence of a tumour.
Therapeutic drug monitoring (TDM) and toxicology
The term Therapeutic Drug Monitoring, TDM for short, refers to the measurement of systemic drug concentrations of drugs in the blood or blood compartments to monitor therapeutic drug administration. The Duotrol Immunoassay allows the monitoring of different drug groups.
– Gentamicin: aminoglycoside antibiotic, used as an emergency drug for severe bacterial infections, especially nosocomial infections.
– Tobramycin: aminoglycoside antibiotic, used e.g. for severe pneumonia, complicated urinary tract infections, abdominal infections.
– Vancomycin: Glycopeptide antibiotic, used for the treatment of infections with Gram-positive bacteria, especially in the therapy of severe staphylococcal infections (MRSA) as a reserve antibiotic.
– Salicylates (e.g. aspirin): Drug against fever, pain, inflammatory diseases
– Benzodiazepines: Polycyclic organic compounds with anxiolytic (anxiety-relieving), sedative (calming), muscle-relaxing (muscle-relaxing) and hypnotic (sleep-inducing), sometimes also anticonvulsive (antispasmodic) effects.
– Phenobarbital: Barbiturate used in the treatment of epilepsy as well as in the preparation of anaesthesia. Can also be used as a sleeping pill.
– Phenytoin: anticonvulsant for the permanent treatment of epilepsy. Can also be used as an antiarrhythmic agent for the treatment of cardiac arrhythmia.
– Valproic acid (VPA): Used to treat epilepsy and seizures and to stabilize mood in bipolar disorders, mania and various types of psychosis or addiction.
Measurements regarding metabolic parameters of different metabolic areas as well as allergy markers can also be checked with the immunoassay quality control.
Duotrol® quality controls
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