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Electrophoresis Controls

Electrophoresis Controls2020-09-03T10:29:27+02:00

Controls for the Serum protein electrophoresis

Electrophoresis, an analytical separation method, is the migration of ions in an electric field to separate charged particles based on their charge, shape and effective size depending on the solution environment and the strength of the electric field.

A subgroup of electrophoresis in laboratory analysis is serum protein electrophoresis. The aim of all serum protein electrophoreses is to detect dysproteinemias (increase or decrease of certain proteins) or paraproteinemias (proteins produced by degenerated cells).

Quality controls for native serum electrophoresis

The Duotrol® Elpho Accuracy Control Sera normal and abnormal are used to monitor the quantitative analytical determinations in serum protein electrophoresis in the normal or pathological range. The lyophilized control sera are based on human serum matrix.

The classical serum protein gel electrophoresis (also: serum electrophoresis), a routine medical laboratory test, is used to separate the serum proteins (proteins of the blood serum) in a native gel electrophoresis for cellulose acetate or agarose.

Quality Control Protein electrophoresis
Control serum Protein electrophoresis
Controls for Serum Protein Capillary Electrophoresis

The Duotrol® Elpho Capillary quality controls in two measuring ranges are used to monitor quantitative analysis determinations in serum protein electrophoresis on capillary electrophoresis systems in the normal range. The lyophilized quality controls have a human serum matrix.

In capillary electrophoresis (also: capillary zone electrophoresis) the separation of proteins takes place in a thin capillary tube in an electrolyte solution. It allows a much more precise separation of the serum proteins.
Protein fractions in serum protein electrophoresis
Albumin is the most important binding and transport protein of the organism and makes up the largest proportion of serum proteins.
α1-Lipoprotein (HDL)
α1-Glycoprotein (Orosomucoid, Acute-Phase-Potein)
Prä-β-Lipoprotein (VLDL/Triglyceride)
β-Lipoprotein (LDL)
Complement fraction C3
Immunglobulin IgG, IgM and IgA
Associated diseases

Changed amounts of individual protein fractions can be an indication for various diseases:

Protein loss syndromes, liver cirrhosis, nephrotic syndrome, chronic inflammatory bowel diseases, acute and chronic inflammation, paraproteinemia, chronic diseases, multiple myeloma, antibody deficiency syndromes, monoclonal gammopathy

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Duotrol® Quality controls

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